GRAVY
The Grand average of hydropathicity (GRAVY) of the linear polypeptide sequence is calculated as the sum of hydropathy values of all amino acids, divided by the number of residues in the sequence. Increasing positive score indicats greater hydrophobicity, but no account is taken of the way the protein folds in three dimensions or the percentage of residues buried in the hydrophobic core of the protein. The calculation is based on the Kyte-Doolittle scale.
Kyte J, Doolittle RF (1982)
A simple method for displaying the hydropathic character of a protein.
J Mol Bio 157 (1), 105-32.
| Hydrophobicity Scales by Kyte-Doolittle |
| Alanine | 1.8 |
| Arginine | -4.5 |
| Asparagine | -3.5 |
| Aspartic acid | -3.5 |
| Cysteine | 2.5 |
| Glutamine | -3.5 |
| Glutamic acid | -3.5 |
| Glycine | -0.4 |
| Histidine | -3.2 |
| Isoleucine | 4.5 |
|
| Leucine | 3.8 |
| Lysine | -3.9 |
| Methionine | 1.9 |
| Phenylalanine | 2.8 |
| Proline | -1.6 |
| Serine | -0.8 |
| Threonine | -0.7 |
| Tryptophan | -0.9 |
| Tyrosine | -1.3 |
| Valine | 4.2 |
|